When B12, folic acid and B6 prove inadequate to lowering homocysteine levels, the addition of TMG often brings the homocysteine levels down.

Sage advice. Im wondering about a post where you said SAMe (S-Adenosylmethionine) and TMG (tri-methyl-glycine) are the same thing Maybe you can illuminate The good news I do know about SAMe is that it stimulates the synthesis of proteoglycans which are building blocks of joint cartilage and it also has anti-depressant qualities.

I think someone may have said this on the forum before, but the quality and way SAMe is handled is real important.

Since TMG is a much cheaper supplement, it is worth trying first.

I took SAMe from June to the middle of December with excellent results.

After about a week of taking nothing and seeing the depression come slogging back into my consciousness, I tried TMG.

Since trying the TMG Im happy again, and my joints feel good so I guess it is working for me SAMe is about a dollar a pill around here whereas I got a large bottle of TMG (maybe 200 pills) for 12.95.

Good luck.

Some of its properties seem to relate to its ability to increase SAMe (S-Adenosyl-Methionine) levels, and some of its properties seem to relate to methylation and its ability to convert into glycine and DMG (di-methyl-glycine).

You will find a lot of information about TMG, DMG and glycine in Dr.

Eric Bravermans book on amino acids.

The liver needs SAMe to perform many of its detoxification functions.

Another benefit for the liver is the lipotropic nature of TMG it helps get rid of fat deposits in the liver.

Another benefit is TMGs ability to increase bile salts and bile production by the liver.

Bile emulsifies fat so it can be absorbed and bile carries toxins out of the liver into the intestines for disposal.

This has been observed with DMG, which is created from TMG.

See page 305 of Bravermans book on amino acids where he is talking about 3 grams of DMG.) Also he says that large doses of SAMe have been a problem with bi-polar depression.

This might have something to do with the increased methylation.

SAMe, DMG and TMG must be kept in balance with folic acid and B12.

These effects might be related to TMGs ability to increase SAMe because SAMe supports normal neural function.

SAMe also helps convert CoA into acetylcholine, which is required for nerve transmissions.

See.

Methyl groups are needed for the proper formation and function of many things like vitamins, hormones, enzymes, and neurotransmitters such as epinephrine.

The methyl groups are also needed for RNA production for protein synthesis.

Methylation is often inhibited by mercury poisoning.

Here are a few notes I took from a tape on methylation that I viewed at my doctors office: A methyl group is a carbon and three hydrogen atoms.

Choline, TMG, and DMG have methyl groups.

Folate helps make methyl groups, and B12 transfers methyl groups.

Kirkman Dmg